The Genomic Integrity is additionally called as hereditary alteration. It is the immediate control of living beings of the genome by utilizing biotechnology. Genes might be evacuated, or "thumped out", utilizing a nuclease. Gene is focusing on an alternate method that utilizations homologous recombination to change an endogenous quality, and this can be utilized to delete gene, expel exons, addition of gene, or to present hereditary transformations. It is an arrangement of advances used to change the hereditary cosmetics of the cell and including the exchange of qualities crosswise over species limits to create enhanced novel life forms. Genes designing does not regularly incorporate customary creature and plant rearing, in vitro treatment, acceptance of polyploidy, mutagenesis and cell combination systems that don't utilize recombinant nucleic acids or a hereditarily altered life form all the while. The maintenance of genome integrity is essential for organism survival and for the inheritance of traits to offspring. Genomic instability is caused by DNA damage, aberrant DNA replication or uncoordinated cell division, which can lead to chromosomal aberrations and gene mutations.